Disease Model Construction Service
In the field of biomedical research, choosing the right model organism is crucial for the construction of disease models. C. elegans has proven to be a powerful tool for constructing disease models. Its genetic and physiological similarities to human make it ideal for simulating the onset and progression of various diseases, including neurodegenerative diseases, metabolic diseases, and infectious diseases. These models provide insights into disease pathology, identifying therapeutic targets and evaluate drug safety and efficacy, providing valuable reference data for clinical trials.
Advantages of C. elegans for Disease Modeling
Efficient Model System: A short life cycle, rapid reproduction, and transparent body structure enable high-throughput screening and detailed study of biological processes, including genetics, development, and aging.
Ease of Genetic Manipulation: With tools like CRISPR/Cas9, MosSCI, and RNA interference, specific genes can be introduced, replaced, knocked out, or temporarily silenced to emulate genetic variations in human diseases.
Genetic and Physiological Similarity: High genetic homology with humans allows C. elegans to effectively mimic human disease mechanisms.
Figure 1 Caenorhabditis elegans as a Model System to Study Human Neurodegenerative Disorders.
( Antonis Roussos, et al., 2023)
Our Services
Our C. elegans model construction services include but are not limited to:
1. Nematode Disease Model Construction Service
As an efficient high-throughput screening model organism, C. elegans shows a high degree of similarity with humans at the genetic and physiological levels. SunyBiotech can build customized a variety of C. elegans disease models for you to accelerate your research work.
2. C. elegans Gene Editing Service
SunyBiotech has extensive experience in gene editing services and can help you precisely modify the genome of C. elegans through CRISPR/Cas9 or MosSCI to introduce, replace or knock out specific genes, or modify specific bases to simulate human disease-related genetic variations.
Related Services
A series order
G series order
