Osmotic Stress Analysis Services

The responses induced by high osmotic pressure include changes in cell cycle progression, coordinated changes in mRNA transcription and translation, protein damage, and increased synthesis of organic substances such as glycerol and trehalose. Maintaining osmotic pressure homeostasis is essential to ensure normal life activities. SunyBiotech aims to use C. elegans as a model organism to study the physiological, molecular and behavioral responses of organisms to osmotic pressure changes. This service enable you analyze the gene expression, cell adaptation mechanism, metabolic changes and survival ability in response to osmotic pressure stress in high or low salt environments.

Our Service includes but are not limited to:

ØOsmotic Stress Model Construction

Induces a stress response after exposing C. elegans to solutions or plates containing different salt concentrations.

ØPhenotypic Stress Response Analysis

Analysis of survival, behavior, physiology, morphology and etc.

ØFluorescence Markers Quantification

Measure fluorescence intensity in transgenic C. elegans with fluorescent markers, with increased fluorescence indicating heightened stress response.

ØAnti-hyperosmotic Stress Compounds Screening

Screen drugs or natural active substances with potential therapeutic value by using C. elegans model.

Fig.1 Survival rate of Caenorhabditis elegans after treatment with hyperosmotic compounds

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