The Histone Chaperone SPT2: A Key Regulator of Chromatin Structure in Metazoa

Histone chaperones are crucial players in the dynamic regulation of chromatin, which is fundamental for processes like gene expression, DNA repair, and replication. The histone chaperones SPT6, SPT5, ASF1 and the HIRA and FACT chaperone complexes have been implicated in...

Using C. elegans to reveal how and why individuals differ in metabolism

Metabolic differences among individuals arise from a complex interplay of genetics, diet, microbiota, and environment. In humans, dissecting these factors is challenging because...

The Surprising Link Between Splicing Errors and Longevity

In the scientific exploration of aging and longevity, RNA splicing, which is a fundamental process in molecular biology, has increasingly become...

In-depth Exploration of the Sensory Neuron Transcriptome: The Mystery of mec-2/Stomatin Splicing

In the nervous system, how individual neurons precisely execute specific functions remains one of the central mysteries in neuroscience. Despite...

The Role of CUT Homeobox Genes in C. elegans

In the development of the nervous system, it’s critical to understand how genes that govern neuronal function are regulated...

How Ionizing Radiation Impacts the Nervous System: Insights from C. elegans and the Role of crm-1

Ionizing radiation is widely used in medicine, industry, and research, but its biological side effects remain a pressing concern. While radiation is well known to...

Exploring the Intricacies of Protein Fatty Acylation in Caenorhabditis elegans: Amino Acid and Protein Specificity

In the fascinating realm of molecular biology, the intricate mechanisms that govern protein function and regulation continue to captivate researchers. One such mechanism that...

Post-Transcriptional Repression of CFP-1: Expanding LIN-41’s Regulatory Toolkit

RNA-binding proteins (RBPs) recognize RNA sequences or structural features through diverse RNA binding domains (RBDs), participate in...

TDP-1 and FUST-1: The Dynamic Duo in Exon Inclusion Inhibition and Fertility Control

Eukaryotic gene expression is a multistep process, and the interaction between different regulatory levels is crucial for coordinating gene expression. Transcription factors (TFs) and RNA-binding proteins (RBPs) are two major classes of proteins that...

The Astonishing Discovery of Glutaminase: The Unsung Hero Behind Sperm Function

Decreased sperm function is one of the major causes of male infertility. In humans, abnormalities in sperm motility, morphology, and quantity can all affect conception. However...