CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice

Obesity is a complex disease associated with having an excess amount of body fat, which can cause complications such as metabolic syndrome, high blood pressure and diabetes. Our bodies contain two typ...

A possible future of curing Type 1 diabetes by genetic editing way

Type 1 diabetes (T1D) is a chronic condition that body’s immune system attack beta cells in the pancrease which produces insulin. It is commonly diagnosed in children or young people. Currently there...

C. elegans can also aid UVR research

The crisp autumn weather makes many people think that UV rays become weaker in the fall and they don't need sun protection. However, the intensity of UV rays is still relatively high in autumn, an...

A3G-BEs-an enhanced CBEs avoiding 'Bystander' cytosines

Cytosine base editors (CBEs) can convert cytosines (C) to thymines (T), which is composed by fusing a deaminase with the Cas9 nickase (nCas9). CBEs are designed to reverse T-to-C mutations in human ge...

A neurotransmitter produced by gut bacteria modulates host sensory behaviour

Specific gut bacteria influenced eating decisions in worms by affecting their response to odors. The findings give insight into how gut microbes may affect behavior in simple organisms.

CRISPR-CasΦ from huge phages is a hypercompact genome editor

CRISPR-Cas systems are found widely in prokaryotes, where they provide adaptive immunity against virus infection and plasmid transformation. In July 2020, team of Jennifer Doudna from University of Ca...

A novel base-pair editing tool for mtDNA——DdCBE

CRISPR has been wildly praised and used for its simple mechanism and efficient base-pair editing of genomic DNAs which has facilitated the exploration of genetic mutation in many diseases. However, mi...

An in vivo genome-wide CRISPR identifies a key regulator of myeloid leukemia

RNA-binding proteins play important roles in maintaining drug resistance of leukemia. In a recent research, team of Dr. Tannishtha Reya from University of California San Diego revealed that the double...

The gene-edited cells are helping: an update of the first patient in the US to get treated for SCD by CRISPR gene editing

Sickle cell disease (SCD) is a group of inherited red blood cell disorders. The disease is caused by a genetic mutation that produces a defective form of hemoglobin, the protein in red blood cells tha...

How Dopamine System Helps coordinate behaviors

To detect on worms for days in a row, Picower Institute scientists think up a open-source microscopy platform.