Overexpression of Mitochondrial Fission or Fusion Genes Enhances Resilience and Extends Longevity

Mitochondria are best known as the cell's power plants, yet their roles extend far beyond ATP production: they buffer calcium, generate redox signals, sponsor autophagy, support innate immunity and orchestrate programmed cell death. Accordingly, defects in mitochondrial gene expression, redox homeostasis, respiratory-chain assembly or membrane structure contribute to age-associated diseases, including neurodegeneration, diabetes and cancer.

Ancient Conserved Transcription Factor Codes: Decoding the Molecular Diversity of Motor Neurons

Motor neurons constitute the principal output units of the nervous system, and their subtype diversity is thought to be relevant to adult-onset neurodegenerative diseases, since distinct motor-neuron subpopulations are known to differ in disease susceptibility.

Genetic Suppressors and a Natural Flavonol Rescue a KIF1A Disease Mutation in C. elegans

KIF1A is a core kinesin motor protein responsible for axonal vesicular transport in neurons.

Unlocking Neural Sexual Dimorphism: Neurotransmitter Remodeling and Multi-Transmitter Co-transmission

Neurotransmitters mediate neuronal signal transmission and serve as key molecules for deciphering behavioral regulation and sexually dimorphic neural circuits in animals.

Not All Lysosomes Are Equal: Organelle Proteomics Links Lysosomal Heterogeneity to Longevity

Lysosomes are essential membrane-bound organelles in eukaryotic cells responsible for degradation and material recycling.

Epidermal Antimicrobial Peptides: A Key Player in Immunity-Induced Sleep

The bidirectional regulatory relationship between sleep and innate immunity has become a hotspot in life sciences.

Dual Pathway Cooperation: How Neurons Regulate Endoplasmic Reticulum Stress

Endoplasmic reticulum (ER) stress is an important physiological response of cells to abnormal protein folding, which is widely involved in the maintenance of physiological homeostasis and the pathogenesis of various diseases.

Unlocking the Molecular Code of Germline Immortality

The perpetuation of life remains one of the most fascinating puzzles in biology: individual organisms are mortal, aging and perishing over time, yet species endure...

Rho-GEF PIX-1: Guardian of Muscle Cell Adhesion

Muscle serves as the body's source of power, and its normal function depends on a series of exquisite cellular structures that ensure both the stability of muscle cells and support...

The Histone Chaperone SPT2: A Key Regulator of Chromatin Structure in Metazoa

Histone chaperones are crucial players in the dynamic regulation of chromatin, which is fundamental for processes like gene expression, DNA repair, and replication. The histone chaperones SPT6, SPT5, ASF1 and the HIRA and FACT chaperone complexes have been implicated in...