As the first multicellular eukaryotic organism to have its genome sequenced, C. elegans is highly homologous to the human genome, which provides unique advantages for studying drug activity, disease models, and biological mechanisms. The locomotor ability of C. elegans relies on its complex nervous system, which as an intuitive phenotype has significant research value. Analyzing movement can provide critical insights into the nervous system, muscle function, aging and toxicological mechanisms.

SunyBiotech leverages years of expertise to accurately assess C. elegans movement, including head swinging, body bending and etc., Whether in the fields of basic scientific research, drug development, toxicity evaluation or aging mechanism research, we deliver comprehensive support and tailored solutions to meet your needs.

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Our analysis of C. elegans motility includes but is not limited to:

ØHead Swing Analysis

C. elegans head swing is driven by neuromuscular coordination. When it moves freely, its head will swing slightly left and right, and then randomly choose one direction to move forward. By measuring head swing frequency over time, we quantify changes in motility.

Fig.1 Frequency of head swing of C. elegans after treatment with a certain drug

ØBody Bending Analysis

C. elegans is usually manifested as sine- or cosine- like body wave during movement. Parameters such as the movement trajectory, path curvature, and movement speed are analyzed to evaluate motility changes.

Fig.2 Statistical analysis of body bending frequency in the model group and the control group within 20 seconds

ØMuscle Strength Analysis

Muscle strength is generally quantitatively assessed by counting the time and number of C. elegans that dig from the bottom of the gel and crawl to the surface of the gel.

Fig.3 Comparison of digging ability of C. elegans in control group and experimental group